CLL response criteria

IWCLL consensus response criteria for chronic lymphocytic leukemia

The International Workshop on Chronic Lymphocytic Leukemia (IWCLL) included updated response criteria in their 2008 publication, “Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia…”

The response categories are:

  • Complete remission (CR), requiring absence of peripheral blood clonal lymphocytes by immunophenotyping, absence of lymphadenopathy, absence of hepatomegaly or splenomegaly, absence of constitutional symptoms and satisfactory blood counts
  • Complete remission with incomplete marrow recovery (CRi), defined as CR above, but without normal blood counts
  • Partial remission (PR), defined as ≥ 50% fall in lymphocyte count, ≥ 50% reduction in lymphadenopathy or ≥ 50% reduction in liver or spleen, together with improvement in peripheral blood counts
  • Progressive disease (PD), defined as ≥ 50% rise in lymphocyte count to > 5 x109/L, ≥ 50% increase in lymphadenopathy, ≥ 50% increase in liver or spleen size, Richter’s transformation, or new cytopenias due to CLL
  • Stable disease, defined as not meeting criteria for CR, CRi, PR or PD

Full details can be found in the original reference.

The International Workshop on Chronic Lymphocytic Leukemia response criteria are a 2008 update of the original 1996 National Cancer Institute Working Group (NCI-WG) guidelines for diagnosis and treatment of for chronic lymphocytic leukemia (CLL).1