CLL immunophenotypic score (Matutes score)
Immunophenotypic score for diagnosis of chronic lymphocytic leukemia
Flow cytometric analysis of peripheral blood or bone marrow is performed for expression of the cell surface markers listed in the table below. The scores for each marker are summed.
A score ≥ 4 is indicative of CLL. A score of ≤ 3 should prompt consideration of an alternative diagnosis.
|Cell surface marker||0 points||1 point|
|CD79b (or CD22)||Strong||Weak|
The original version of this immunophenotypic scoring system for chronic lymphocytic leukemia (CLL), also known as the CLL score or Matutes score, was published in 1994.1 A modification of the scoring system, substituting CD22 with CD79b, was proposed in 1997.2
FMC7: an antibody clone identifying an epitope of CD20
SmIg: surface membrane immunoglobulin
- Matutes E, Owusu-Ankomah K, Morilla R, Garcia Marco J, Houlihan A, Que TH et al. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia 1994; 8: 1640-5.
- Moreau EJ, Matutes E, A’Hern RP, Morilla AM, Morilla RM, Owusu-Ankomah KA et al. Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b). Am J Clin Pathol 1997; 108: 378-382.