Follicular Lymphoma International Prognostic Index (FLIPI) Calculator

Prognostic score for newly-diagnosed follicular lymphoma

Applies at the time of diagnosis.

1. Sum the number of risk factors to calculate the FLIPI score

2. Determine risk category and prognosis

FLIPI scoreRisk category% of patients1Median PFS (m)2
0 or 1Good3684
2Inter­mediate3770
3 - 5Poor2742
Commentary

The Follicular Lymphoma International Prognostic Index (FLIPI) derives from a multivariate analysis of survival of 4171 patients diagnosed between 1985 and 1992.1 Patients who were treated received a range of chemotherapies, none including rituximab.

The FLIPI retains prognostic relevance in the era of rituximab.2,3,4 However, a FLIPI-2 scoring system has also been published, incorporating beta 2 microglobulin levels, and applied at the time of first therapy in a cohort that largely received chemoimmunotherapy.5

Acronyms

FLIPI: follicular lymphoma international prognostic index
LDH: lactate dehydrogenase
m: months
OS: overall survival
PFS: progression-free survival