Follicular Lymphoma International Prognostic Index (FLIPI) Calculator
Prognostic score for newly-diagnosed follicular lymphoma
Applies at the time of diagnosis.
1. Sum the number of risk factors to calculate the FLIPI score
2. Determine risk category and prognosis
|FLIPI score||Risk category||% of patients1||Median PFS (m)2|
|0 or 1||Good||36||84|
|3 - 5||Poor||27||42|
The Follicular Lymphoma International Prognostic Index (FLIPI) derives from a multivariate analysis of survival of 4171 patients diagnosed between 1985 and 1992.1 Patients who were treated received a range of chemotherapies, none including rituximab.
The FLIPI retains prognostic relevance in the era of rituximab.2,3,4 However, a FLIPI-2 scoring system has also been published, incorporating beta 2 microglobulin levels, and applied at the time of first therapy in a cohort that largely received chemoimmunotherapy.5
FLIPI: follicular lymphoma international prognostic index
LDH: lactate dehydrogenase
OS: overall survival
PFS: progression-free survival
- Solal-Céligny P, Roy P, Colombat P, White J, Armitage JO, Arranz-Saez R et al. Follicular lymphoma international prognostic index. Blood 2004; 104: 1258-1265
- Nooka AK, Nabhan C, Zhou X, Taylor MD, Byrtek M, Miller TP et al. Examination of the follicular lymphoma international prognostic index (FLIPI) in the National LymphoCare study (NLCS): a prospective US patient cohort treated predominantly in community practices. Ann Oncol 2013; 24: 441-8.
- Marcus R, Imrie K, Solal-Celigny P, Catalano JV, Dmoszynska A, Raposo JC et al. Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma. J Clin Oncol 2008; 6: 4579-4586
- Salles G, Seymour JF, Offner F, López-Guillermo A, Belada D, Xerri L et al. Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial. Lancet 2011; 377: 42-51
- Federico M, Bellei M, Marcheselli L, Luminari S, Lopez-Guillermo A, Vitolo U et al. Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project. J Clin Oncol 2009; 27: 4555-62