Follicular Lymphoma International Prognostic Index 2 (FLIPI2) Calculator

Prognostic score for untreated follicular lymphoma

Applies at the time of first treatment.

1. Sum the number of risk factors to calculate FLIPI-2 score

2. Determine risk category and prognosis

FLIPI-2 scoreFLIPI-2 risk category5 year PFS (%)15 year PFS (%)2
0Low risk8076
1 - 2Intermediate risk5149
3 - 5High risk1937

The Follicular Lymphoma International Prognostic Index-2 (FLIPI2) derives from a multivariate analysis of survival of 832 patients receiving first treatment for follicular lymphoma between 2003 and 2005, followed-up for a median of 38 months.1 The model was validated in an external cohort of 231 patients. Patients received a range of treatments, the majority (59%) including rituximab. The FLIPI2 has been validated in patients treated uniformly with R-CHOP chemotherapy.2

Unlike the original FLIPI,3 which measures survival from diagnosis, the FLIPI2 is applied at the time of treatment for follicular lymphoma. Other differences are that the FLIPI2 was developed in the era of chemoimmunotherapy with rituximab, and that a more complete dataset, including beta 2 microglobulin levels, was available to the FLIPI2 investigators.


FLIPI: follicular lymphoma international prognostic index
LDH: lactate dehydrogenase
OS: overall survival