Simplified MIPI Calculator

Simplified prognostic index for advanced-stage mantle cell lymphoma

Applies at the time of first treatment.

1. Evaluate each risk factor to calculate simplified MIPI score

2. Determine risk category and prognosis

s-MIPI scores-MIPI risk categoryMedian TTF (years)15 year OS (%)1
0 - 3Low risk6.381
4 or 5Intermediate risk3.863
6 or higherHigh risk1.435
Commentary

The Mantle Cell Lymphoma International Prognostic Index (MIPI) derives from multivariate analysis of survival of 455 patients with mantle cell lymphoma treated between 1996 and 2004.2 Patients were treated with chemotherapies including CHOP, R-CHOP and MCP.

Whereas the full MIPI and MIPIb use complex formulas to treat prognostic factors as continuous variables, the simplified MIPI assigns each factor a score from 0 to 3. An overall risk score is determined by summing of the ratings for each factor.

In an analysis of a large independent cohort of patients treated within clinical trials, s-MIPI was recommended over the MIPI for routine clinical use, as it showed comparable prognostic performance while being easier to use.1 The s-MIPI retains prognostic relevance in patients uniformly treated with intensive chemoimmunotherapy followed by autologous stem cell transplantation.3

Acronyms

LDH: lactate dehydrogenase
MIPI: mantle cell lymphoma international prognostic index
OS: overall survival
TTF: time to treatment failure