IPSET-thrombosis Score Calculator

International Prognostic Score for Thrombosis in Essential Thrombocythemia (ET)

The IPSET-thrombosis applies to patients meeting WHO diagnostic criteria for ET.

2. Determine risk group and prognosis

ScoreRisk categoryAnnual thrombosis risk
0 - 1Low1.03%
2Intermediate2.35%
3 - 6High3.56%

Commentary

The IPSET-thrombosis model derives from multivariate analysis of 891 patients diagnosed with ET by WHO criteria within the preceding year, at one of seven centers. Most high-risk patients received cytoreductive therapy with hydroxyurea, anagrelide or busulfan, while most low-risk patients did not. Most patients (68%) received low-dose aspirin. The outcome variable was major thrombosis, defined as any of: venous thromboembolism, ischemic stroke, transient ischemic attack, myocardial infarction, or peripheral arterial thrombosis. The model was validated in an external cohort of 329 patients.1

References

  1. Barbui T, Finazzi G, Carobbio A, Thiele J, Passamonti F, Rumi E et al. Development and validation of an International Prognostic Score of thrombosis in World Health Organization-essential thrombocythemia (IPSET-thrombosis). Blood 2012; 12: 5128-33.